2019—2020年北京医院住院患者人血白蛋白注射液的临床应用情况调查与分析

Investigation and Analysis of Clinical Application of Human Albumin Injection in Inpatients of Beijing Hospital from 2019 to 2020

目的:探讨北京医院(以下简称“我院”)住院患者使用人血白蛋白注射液的情况,评价其使用的规范合理性,为临床治疗提供参考。方法:采用回顾性调查法,利用信息化系统调取2019—2020年我院住院患者中使用人血白蛋白注射液患者的相关数据,采用Excel 2007及SPSS 21.0软件对患者年龄、临床诊断、用药疗程、使用剂量以及用药前的血清白蛋白水平等分别进行筛选、统计与分析。结果:2019—2020年我院共5685例住院患者使用人血白蛋白注射液(其中2019年2848例,2020年2837例),涉及33个科室,以胸外科、普外科患者用药量较多;个人日用药量以20~70 g居多;用药疗程主要集中在2、3 d;大部分患者用药前血清白蛋白水平<30 g/L;符合药品说明书推荐的7类适应证的共1433例(占25.21%),主要为防治低蛋白血症、成人呼吸窘迫综合征;符合UHC指南适应证的有1090例(占19.17%),用药原因主要为低蛋白血症。结论:我院人血白蛋白注射液的使用较广泛,在临床应用中仍存在一些误区,需加强对其合理使用的监管力度,医师应严格掌握人血白蛋白注射液的适应证,谨慎用药。

OBJECTIVE:To probe into the clinical application of human albumin injection in inpatients of Beijing Hospital(hereinafter referred to as“our hospital”),and to evaluate the application rationality,so as to provide reference for clinical treatment.METHODS:Retrospective analysis was adopted,the information system was used to collect the relevant data of inpatients with human albumin injection in our hospital from 2019 to 2020.Excel 2007 and SPSS 21.0 were used to screen,statistically analyze the patients’age,clinical diagnosis,medication course,dosage and serum albumin level before medication.RESULTS:From 2019 to 2020,a total of 5685 inpatients in our hospital used human albumin injection(with 2848 cases in 2019 and 2837 cases in 2020),including 33 departments,and patients in the thoracic surgery and general surgery were more likely to use the drugs.The majority of personal daily dosage was from 20 g to 70 g.The course of medication was mainly 2 d and 3 d.The serum albumin level of most patients before medication was less than 30 g/L.A total of 1433 cases(25.21%)complied with the seven indications recommended in the drug instructions,mainly for the prevention and treatment of hypoproteinemia and adult respiratory distress syndrome.There were 1090 cases(19.17%)in line with UHC guideline indications,and the main reason for medication was hypoproteinemia.CONCLUSIONS:Human albumin injection is widely used in our hospital,and there are still some misunderstandings in clinical application.It is necessary to strengthen the supervision of its rational application.Clinicians should strictly grasp the indications of human albumin injection and use drugs with caution.