深圳市17589例体检人群中幽门螺杆菌分型结果分析

Analysis of the typing results of Helicobacter pylori in 17589 cases of physical examination in Shenzhen

目的了解华中科技大学协和深圳医院体检人群幽门螺杆菌(Hp)亚型血清IgG抗体检测结果,探讨亚型与性别和年龄之间的关系。方法检测体检人群血清Hp CagA、VacA、UreB、UreA的IgG抗体,对数据进行桑基图可视化展示和χ^(2)检验。结果>35~60岁年龄段是Hp IgG抗体分型检测体检的主要人群,其次是>18~35岁年龄段。Ⅰ型和Ⅱ型Hp IgG抗体总阳性率为49.06%,其中Ⅰ型阳性率为32.69%,Ⅱ型阳性率为16.37%。不同性别间Ⅰ型和Ⅱ型Hp阳性率、Ⅰ型的亚型构成差异均无统计学意义(P>0.05),不同年龄段之间Ⅰ型和Ⅱ型Hp阳性率、Ⅰ型的亚型构成差异均无统计学意义(P>0.05)。结论深圳市体检人群Hp IgG抗体阳性率为49.06%,性别和年龄对Hp总阳性率和不同型别阳性率无影响。

Objective To understand the results of detection of Helicobacter pylori(Hp)subtype IgG antibody in serum from physical examination population in Union Shenzhen Hospital,Huazhong University of Science and Technology,and to explore the relationship between subtypes and gender and age.Methods The IgG antibodies of CagA,VacA,UreB and UreA of Helicobacter pylori in serum from physical examination population were detectedn,and the data were presented with the Sankey diagram and analyzed with Chi-square test.Results The>35-60 year-old people are the main population of Hp IgG antibody detection,followed by young people aged>18-35.The total positive rate of subtypeⅠandⅡIgG antibody was 49.06%,in which the positive rate of subtypeⅠwas 32.69%,and the positive rate of typeⅡwas 16.37%.There was no significant difference in the positive rate of Hp of typeⅠand typeⅡ,or the composition of subtypes of typeⅠbetween different genders(P>0.05).There was no significant difference in the positive rate of Hp of typeⅠand typeⅡ,or the composition of subtypes of typeⅠamong different age groups(P>0.05).Conclusion The positive rate of Hp IgG antibody in Shenzhen physical examination population is 49.06%,gender and age have no impact on the total positive rate of Hp and the positive rate in different subtypes.