长链非编码RNA参与中药活性成分抗肺癌的研究进展

Research progress of long non coding RNA involved in active components of traditional Chinese medicine against lung cancer

肺癌的发病率和病死率均位于恶性肿瘤的首位,寻找新的防治策略已刻不容缓。中药活性成分因其安全、天然的特性而备受关注,但其抗肺癌机制仍待阐明。该文主要介绍几种中药活性成分通过调控长链非编码RNA发挥其抗肺癌作用,包括紫杉醇、表没食子儿茶素没食子酸酯、姜黄素、白藜芦醇、水飞蓟素和血根碱等,为中药活性成分抗肺癌作用提供了新的分子机制和理论基础。

The incidence and mortality of lung cancer are in the first place of malignant tumor,and it is urgent to find new prevention and treatment strategies.The active components of traditional Chinese medicine have attracted much attention due to their safety and natural properties,but their anti-lung cancer mechanisms are still to be clarified.This article mainly introduced the anti-lung cancer effect of several active components of traditional Chinese medicine by regulating long non coding RNA,including paclitaxel,epigallocatechin gallate,curcumin,resveratrol,silymarin and hemagline,aiming at providing new molecular mechanisms and theoretical basis for the anti-lung cancer effect of the active components of Chinese medicine.