氯吡格雷联合阿司匹林急诊治疗在急性心肌梗死患者中的应用

Application of clopidogrel combined with aspirin in emergency treatment of patients with acute myocardial infarction

目的分析氯吡格雷联合阿司匹林急诊治疗在急性心肌梗死患者中的应用。方法80例急性心肌梗死患者随机分为对照组与研究组,各40例。对照组选择阿司匹林肠溶片进行治疗,研究组在对照组基础上,采用氯吡格雷片进行治疗。比较两组治疗前后心功能指标、炎症反应及不良反应发生情况。结果治疗3个月后,研究组左室射血分数(LVEF)与心输出量(CO)水平均高于对照组,左心室收缩末期内径(LVESD)及左心室舒张末期内径(LVEDD)水平均低于对照组,差异均具有统计学意义(P<0.05)。治疗3个月后,研究组白细胞介素-10(IL-10)水平为(6.72±0.93)ng/ml高于对照组的(4.58±0.97)ng/ml,白细胞介素-6(IL-6)水平为(19.11±2.34)ng/ml低于对照组的(24.58±3.62)ng/ml,差异均具有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论氯吡格雷联合阿司匹林治疗急性心肌梗死的效果理想,对于心功能以及炎症反应的改善具有促进作用,且用药安全性高,临床可进一步推广运用。

Objective To analyze the application of clopidogrel combined with aspirin in emergency treatment of patients with acute myocardial infarction.Methods A total of 80 patients with acute myocardial infarction were randomly divided into control group and research group,with 40 cases in each group.The control group was treated with aspirin enteric-coated tablets,and the research group was treated with clopidogrel tablets based on the control group.The cardiac function indicators and inflammatory response before and after treatment,and occurrence of adverse reactions were compared between the two groups.Results After 3 months of treatment,the left ventricular ejection fraction(LVEF)and cardiac output(CO)levels were higher than those of the control group,and the left ventricular end systolic diameter(LVESD)and left ventricular end diastolic diameter(LVEDD)were lower than those of the control group,and the difference was statistically significant(P<0.05).After 3 months of treatment,the interleukin-10(IL-10)(6.72±0.93)ng/ml of the research group was higher than(4.58±0.97)ng/ml of the control group,and the interleukin-6(IL-6)(19.11±2.34)ng/ml was lower than(24.58±3.62)ng/ml of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusion Combination of clopidogrel and aspirin shows ideal effect on the treatment of acute myocardial infarction,and it can improve the cardiac function and inflammatory response with high safety,which can be further promoted and applied in clinic.