甘精胰岛素与阿卡波糖联合对老年2型糖尿病的治疗价值评估

Evaluation on the value of the combination of insulin glargine and acarbose in the treatment of type 2 diabetes mellitus in the elderly

目的探究甘精胰岛素与阿卡波糖联合对老年2型糖尿病的治疗效果。方法98例老年2型糖尿病患者,采用抽签法分为实验组和对照组,各49例。对照组患者实施甘精胰岛素治疗,实验组患者采用甘精胰岛素与阿卡波糖联合治疗。对比两组患者血糖相关指标[空腹血糖(FPG)、餐后2 h血糖(2 h PG)和糖化血红蛋白(HbA1c)]、临床治疗效果以及不良反应发生情况。结果治疗后,实验组患者FPG、2 h PG、HbA1c水平均低于治疗前,且实验组患者低于对照组,差异具有统计学意义(P<0.05)。实验组患者临床总有效率95.92%高于对照组的83.67%,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论针对老年2型糖尿病患者,应用甘精胰岛素与阿卡波糖联合治疗的效果显著,安全性较高,值得临床推广。

Objective To investigate the therapeutic effect of combination of insulin glargine and acarbose in the treatment of type 2 diabetes mellitus in the elderly.Methods A total of 98 elderly patients with type 2 diabetes mellitus were divided into experimental group and control group according to lottery method,with 49 cases in each group.The control group was treated with insulin glargine,and the experimental group was treated with insulin glargine and acarbose.The blood glucose related indicators[fasting plasma glucose(FPG),2 h postprandial glucose(2 h PG)and glycosylated hemoglobin(HbA1c)],clinical effect and occurrence of adverse reactions were compared between the two groups.Results After treatment,the levels of FPG,2 h PG and HbA1c of the experimental group were lower than those before treatment,and the experimental group was lower than the control group.All the difference was statistically significant(P<0.05).The total clinical effective rate 95.92%of the experimental group was higher than 83.67%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusion Combination of insulin glargine and acarbose has significant effect in the treatment of type 2 diabetes mellitus in the elderly with high safety,and it is worthy of clinical promotion.