奥氮平联用碳酸锂治疗双相情感障碍的疗效分析

Analysis of the efficacy of olanzapine combined with lithium carbonate in the treatment of bipolar disorder

目的分析双相情感障碍治疗中奥氮平联用碳酸锂的临床效果。方法100例双相情感障碍躁狂发作或混合状态患者,随机分为观察组与对照组,每组50例。对照组患者单用奥氮平治疗,观察组患者采用奥氮平联合碳酸锂治疗。对比两组患者治疗前后的贝克-拉范森躁狂量表(BRMS)评分,治疗效果,不良反应发生情况。结果治疗前,两组患者的BRMS评分对比,差异无统计学意义(P>0.05);治疗后,两组患者的BRMS评分均低于本组治疗前,且观察组患者的BRMS评分(16.8±3.6)分低于对照组的(22.0±6.5)分,差异具有统计学意义(P<0.05)。观察组患者的治疗总有效率为94.0%,高于对照组的72.0%,差异具有统计学意义(P<0.05)。观察组患者的不良反应发生率18.0%低于对照组的36.0%,差异具有统计学意义(P<0.05)。结论将奥氮平联合碳酸锂应用在双相情感障碍患者治疗中,在改善患者预后的同时,可降低不良反应发生率,且该种治疗方式经济性较高,值得临床中采纳。

Objective To analyze the clinical effect of olanzapine combined with lithium carbonate in the treatment of bipolar disorder.Methods A total of 100 patients with mixed and manic bipolar disorder were randomly divided into observation group and control group,with 50 cases in each group.The control group was treated with olanzapine,and the observation group was treated with olanzapine and lithium carbonate.The Bech-Rafaelsen mania rating scale(BRMS)score before and after treatment,therapeutic effect,and occurrence of adverse reactions were compared between the two groups.Results Before treatment,there was no statistically significant difference in BRMS score between the two groups(P>0.05).After treatment,the BRMS score of the two groups were lower than that before treatment,and the BRMS score(16.8±3.6)points of the observation group was lower than(22.0±6.5)points of the control group.All the difference was statistically significant(P<0.05).The total effective rate of the observation group was 94.0%,which was higher than 72.0%of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 18.0%of the observation group was lower than 36.0%of the control group,and the difference was statistically significant(P<0.05).Conclusion The application of olanzapine and lithium carbonate for patients with bipolar disorder can improve the prognosis of patients and reduce the incidence of adverse reactions.This treatment method has high economy,and it is worthy of clinical adoption.