β受体拮抗剂联合替莫唑胺治疗转移性副神经节瘤病例报告分析

Case report analysis ofβ-receptor antagonist combined with temozolomide in the treatment of metastatic paraganglioma

目的探讨转移性副神经节瘤的特点,以此提高临床对转移性副神经节瘤的临床认识和诊治水平。方法回顾性分析1例转移性副神经节瘤的临床资料及诊治经过,复习文献,对转移性副神经节瘤的特点进行讨论。结果1例67岁男性转移性副神经节瘤患者,反复血压波动大且贫血,二线经过β受体拮抗剂联合替莫唑胺治疗患者肿瘤缩小,血压恢复平稳,贫血改善,获得>7个月的无进展生存。结论运用β受体拮抗剂联合替莫唑胺成功治疗1例转移性副神经节瘤。

Objective To discuss the characteristics of metastatic paraganglioma,so as to improve the clinical understanding and diagnosis and treatment of metastatic paraganglioma.Methods The clinical data,diagnosis and treatment of 1 case of metastatic paraganglioma were analyzed retrospectively.The characteristics of metastatic paraganglioma were discussed by reviewing the literature.Results A 67-year-old male patient with metastatic paraganglioma had recurrent blood pressure fluctuation and anemiaβ.After a second-line therapy ofβ-receptor antagonist and temozolomide,patient has shrank tumor,stable blood pressure,improved anemia,and the patient achieves progression-free survival for>7 months.