内脏脂肪型丝氨酸蛋白酶抑制剂与临床疾病关系的研究进展

Relationship Between Visceral Adipose Tissue-derived Serine Protease Inhibitor and Clinical Diseases

内脏脂肪型丝氨酸蛋白酶抑制剂(Vaspin)是内脏脂肪组织分泌的一种细胞因子,参与机体氧化应激和炎症反应,可改善胰岛素抵抗,具有抗动脉粥样硬化等作用。Vaspin在糖尿病及其慢性并发症、冠状动脉疾病及多囊卵巢综合征等疾病中发挥着一定的作用。本文总结关于Vaspin的国内外研究数据,为相关疾病的早期筛查和治疗提供新思路。

Visceral adipose tissue-derived serine protease inhibitor(Vaspin)is a cytokine secreted by visceral adipose tissue,which is involved in oxidative stress and inflammation,can improve insulin resistance,and resist arteries atherosclerosis.Vaspin plays a certain role in diabetes,chronic complications,coronary artery disease,and polycystic ovary syndrome.This article summarizes the domestic and foreign research data on Vaspin,and provides new ideas for clinical early screening and treatment of related diseases.