摘要
目的:观察双歧杆菌三联活菌联合蛋白琥珀酸铁治疗小儿营养性缺铁性贫血(NIDA)的临床疗效及其对铁储备、免疫功能的影响。方法:将108例NIDA患儿分为观察组和对照组,每组各54例;对照组患儿予以蛋白琥珀酸铁口服溶液,观察组在对照组的基础上加服双歧杆菌三联活菌胶囊,两组均连续治疗8周。观察两组患儿血清铁(SI)、铁蛋白(SF)、转铁蛋白(TRF)、血红蛋白(Hb)、红细胞计数(RBC)、平均红细胞容积(MCV)、平均红细胞血红蛋白含量(MCH)等贫血相关指标变化;检测患儿免疫功能指标(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+));记录药物不良反应。结果:治疗8周后,观察组总有效率为94.44%,高于对照组的79.63%(P<0.05);两组SI、SF水平均较治疗前升高(P<0.05)、TRF水平均较治疗前降低(P<0.05),且观察组的SI、SF水平高于对照组(P<0.05),TRF水平低于对照组(P<0.05);两组Hb、RBC、MCV、MCH水平均较治疗前升高(P<0.05),且观察组优于对照组(P<0.05);两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均较治疗前升高(P<0.05),且观察组均高于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:蛋白琥珀酸铁与双歧杆菌三联活菌联用治疗小儿NIDA的疗效高于蛋白琥珀酸铁单用,可改善患儿的铁储备,增强免疫力,且安全性较高。
Objective:To observe the effect of bifid-triple viable capsule combined with iron protein succinylate in the treatment of nutritional iron deficiency anemia(NIDA)in children and its influence on iron reserve and immune function.Methods:A total of 108 children patients with NIDA were divided into observation group and control group,with 54 cases in each group.Control group was treated with iron protein succinylate oral solution,and observation group received iron protein succinylate oral solution^(+)bifid-triple viable capsule.After 8 weeks of continuous treatment,the clinical efficacy was evaluated.The changes in anemia-related indicators such as serum iron(SI),ferritin(SF),transferrin(TRF),hemoglobin(Hb),red blood cell count(RBC),mean corpuscular volume(MCV)and mean corpuscular hemoglobin(MCH)were observed among the children patients.The immune function indicators(CD3^(+),CD4^(+),CD4^(+)/CD8^(+))were detected,and the adverse drug reactions were recorded.Results:After 8 weeks of treatment,the total effective rate of observation group was significantly higher than that of control group(94.44%vs.79.63%,P<0.05).The levels of SI and SF in the two groups were increased compared with those before treatment(P<0.05),while the level of TRF was decreased compared with that before treatment(P<0.05),and the levels of SI and SF of observation group were significantly higher than those of control group(P<0.05),while the level of TRF was significantly lower than that of control group(P<0.05).The Hb,RBC,MCV and MCH in the two groups were increased compared with those before treatment(P<0.05),and the observation group were significantly higher than the control group(P<0.05).The levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the two groups were increased compared with those before treatment(P<0.05),and the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)of observation group were significantly higher than those of control group(P<0.05).There was no significant difference in the total incidence rate of adverse reactions between the two groups(P>0.05).Conclusion:On the basis of iron supplementation with protein succinylate in children patients with NIDA,the combined application of bifid-triple viable capsule can further improve the therapeutic effect,and has a positive significance in improving the iron reserve and strengthening immunity of children patients,with good safety.
作者
伍玉梅
文川
WU Yu-mei;WEN Chuan(Department of Pediatrics,the Second Xiangya Hospital of Central South University,Changsha 410011,Hunan,China)
出处
《川北医学院学报》
CAS
2021年第8期1072-1075,共4页
Journal of North Sichuan Medical College
关键词
营养性缺铁性贫血
儿童
蛋白琥珀酸铁
双歧杆菌三联活菌
疗效
免疫功能
Nutritional iron deficiency anemia
Children
protein succinylate
Bifid-triple viable capsule
Efficacy
Immune function