电感耦合等离子体质谱法在不同药典中的方法体系和在中药无机成分研究中的应用进展

Method System in Different Pharmacopoeias and Application Progress in Study of Inorganic Components of Traditional Chinese Medicine of ICP-MS

为科学指导中药安全性标准的建立和合理评价中药的安全性和有效性,通过比较中国、美国及欧洲等药典电感耦合等离子体质谱法[ICP-MS,包括高效液相色谱(HPLC)-ICP-MS]通则方法及技术体系,综述了药典中ICP-MS的方法体系及在中药(动物药、植物药或矿物药)中重金属元素及有害元素、元素形态或价态检测中的技术规范和应用范围;通过相关文献整理,综述了ICP-MS在中药无机成分安全性评价及风险评估、无机元素谱及质量评价和有害元素形态及价态等方面的应用进展,并对ICP-MS新技术和方法在中药研究的应用前景进行了展望(引用文献57篇)。

In order to scientifically guide the establishment of safety standards for traditional Chinese medicines and rationally evaluate the safety and effectiveness of traditional Chinese medicines,method general rules and technical systems about ICP-MS,including HPLC-ICP-MS in the Chinese,American and European pharmacopoeias compared,and method systems in the pharmacopoeias and technical specifications and scopes of application in the analysis of healy metal and harmful elements and their element forms or valences about ICP-MS in traditional Chinese medicines(animal medicine,botanical medicine or mineral medicine)were reviewed.The application progress of ICP-MS in the safety evaluation and risk assessment of the inorganic components of traditional Chinese medicines,the inorganic element spectrum and quality evaluation,and the form and valence of harmful elements were reviewed by the sorting of relevant references.The application prospects of new technologies and methods in traditional Chinese medicine research were prospected(57 references cited).