Estrogen and cerebral small vessel disease

To the Editor:Cerebral small vessel disease(CSVD)refers to a wide spectrum of pathological processes,which affects the small arteries,arterioles,venous,and capillaries in the brain.This disease causes cognitive,psychological,and physical disabilities and is responsible for up to 45%of vascular dementia in the elderly.With the prolongation of human life expectancy,the medical expense and family burden of cognitive disorders in the elderly increasingly aggravate,and the early identification and effective treatment of CSVD are receiving increasing attention.