Clinical practice guideline of BRCA1/2 testing for patients with breast cancer: Chinese Society of Breast Surgery (CSBrS) practice guideline 2021

Breast cancer is the most common female cancer around the world.Approximately 5%to 10%of breast cancer is associated with a hereditary predisposition from inherited germline mutations,[1]with about 15% of mutations occurring in the breast cancer susceptibility genes(BRCA1/2).[2-4]Individuals carrying BRCA1/2 mutations may reduce their risk of breast cancer through screening and preventing managements.