肺微生物组群与肺癌相关性研究进展

Research advances of lung microbiome in lung cancer

近年来,肺微生物群落的研究受到关注,已知肺微生物群落菌群失调与某些肺部疾病相关,如囊性纤维化、支气管哮喘、COPD、支气管扩张等,同时越来来越多的研究发现,肺微生物组群作为一个整体或组成部分成为了肺癌发展的新危险因素,肺微生物群落的改变可能有助于癌症的持续生长和扩散。了解肺微生物组群及肺微生物组群与肺癌发生发展的相互关系,可能会发现肺癌新的病因、诊断生物标志物及治疗靶点,为肺癌诊治开辟一个新的研究范式,改善肺癌预后。本篇文章对肺微生物组与肺癌之间相互关系的研究进行综述。

In recent years,attention has been paid to the study of pulmonary microbial community.Disorders of the pulmonary microbiome are known to be associated with certain lung diseases such as cystic fibrosis(CF),asthma,chronic obstructive pulmonary disease(COPD),bronchiectasis.Furthermore,more and more studies have found that the lung microbiome as a whole or a component has become a new risk factor for the development of lung cancer,and changes in the lung microbiome may contribute to the infiltration metastasis of cancer.The study on the relationship between lung microbiome and lung cancer may discover new causes,diagnostic biomarkers and therapeutic targets of lung cancer,develop new research paradigm for the diagnosis and treatment of lung cancer,and improve the prognosis of lung cancer.This article reviews the latest research on lung microbiome in the development of lung cancer.