水通道蛋白4在神经退行性疾病中的研究进展

Recent advance of aquaporin-4 in neurodegenerative diseases

神经退行性疾病是以神经元的进行性丢失为特征的一类疾病,病因尚不明确。水通道蛋白4(AQP4)是水通道蛋白家族的成员,对维持脑内水稳态起到重要作用。近年研究发现AQP4具有通过类淋巴系统引流脑组织代谢废物、参与物质交换等功能。文中总结了目前AQP4在帕金森病、阿尔茨海默病等神经退行性疾病的发病及进展过程中的作用,并提出未来的研究方向。

Neurodegenerative disease is a type of disease characterized by the progressive loss of neurons,the cause of which is not clear.Aquaporin-4(AQP4)is a member of the aquaporin family,which plays an important role in maintaining water homeostasis in the brain.In recent years,researchers found that AQP4 has the functions of draining brain metabolic wastes and participating in material exchange through the glmphatic system.This review aims to summarize the current researches of AQP4 in the pathogenesis and progression of neurodegenerative diseases such as Parkinson′s disease and Alzheimer′s disease,and to propose future research directions.