多环多异戊烯基间苯三酚类天然产物的研究进展

Research progress of polycyclic polyprenylated acylphloroglucinols natural products

多环多异戊烯基间苯三酚衍生物(polycyclic polyprenylated acylphloroglucinols,PPAPs)化学结构复杂多变且药理活性广泛,已成为当前天然产物的研究热点之一。特别是其中部分PPAPs,不仅具有新颖的非传统骨架,同时也可能蕴藏了更多未知的活性,对于先导化合物的开发有着重要意义。对近年来分离鉴定的具有非传统骨架类型的PPAPs的结构、来源、生物合成途径以及药理活性进行综述,以期为此类化合物的进一步研究提供参考。

Due to their fascinating chemical structures and extensive pharmacological activities, polycyclic polyprenylated acylphloroglucinols(PPAPs) have become one of the current research hotspots of natural products. In particular, some of the PPAPs not only have novel non-traditional skeleton types, but also contain more unknown possible activities, which are of great significance for the development of lead compounds. The structure, source, biosynthetic pathway and pharmacological activities of PPAPs with non-traditio-nal skeleton types isolated and identified in recent years are reviewed, in order to provide references for further research on such compounds.