女性血液透析患者肥胖与骨密度的相关性

Relationship of obesity and bone mineral density in female patients undergoing hemodialysis

目的探讨女性血液透析患者肥胖与骨密度的相关性。方法随机选取行血液透析的肥胖女性患者50例(观察组)和健康体检的肥胖女性30例(对照组),收集两组临床资料,检测相关指标,包括血脂指标、骨代谢指标和骨密度指标,分析肥胖与骨密度的相关性。结果与对照组比较,观察组患者腰围、内脏脂肪指数、FBG、餐后2 h血糖、TC、TG、LDL和骨代谢相关指标均升高(P<0.05),HDL水平降低(P<0.05)。与对照组比较,观察组患者L2~L4腰椎段、股骨大转子、粗隆间及股骨颈和华氏三角处骨密度均降低(P<0.05)。结论女性血液透析肥胖患者骨密度较正常者降低。对女性血液透析患者定期做好骨密度的检测,并及时采用有效措施改善低骨密度具有重要意义。

Objective To explore the relationship of obesity and bone mineral density(BMD) in female patients undergoing hemodialysis.Methods The clinical data of 50 obese female patients undergoing hemodialysis(group A) and 50 obese physical examination women(group B) were collected, who were examined with blood lipids, bone metabolism and BMD.The relationship of obesity and BMD was analyzed.Results Compared with group B,the waist circumference, visceral fat index, FBG,2 h PG,TC,TG,LDL and bone metabolism-related indexes in group A were significantly increased(P<0.05),while the HDL level was significantly decreased(P<0.05).Compared with group B,the BMD of L2-L4 lumbar segments, greater trochanter, intertrochanteric, femoral neck and Fahrenheit triangle in group A were significantly decreased(P<0.05).Conclusion The BMD of obese female hemodialysis patients is significantly lower than that of normal obese women.It has an important role to regularly detect the BMD and take the effective measures to improve decreased BMD in female hemodialysis patients with obesity.