结直肠癌肝转移转化治疗进展

Recent advances in the treatment of colorectal liver metastasis

结直肠癌(colorectal cancer, CRC)是腹部常见的恶性肿瘤之一,发病率居全球肿瘤发病的第3位,死亡率居肿瘤致死病因的第2位。结直肠癌肝转移(colorectal liver metastases, CRLM)是结直肠癌治疗的重点和难点,也是影响病人预后的主要因素。目前手术治疗仍然是治愈CRLM的最佳手段,但初始可切除率仅10%~20%。因此,使大量的初始不可切除的CRLM病人转化为可切除,具有重要的临床意义。此文就目前CRLM转化治疗的内涵、治疗方法及疗效等研究进展加以综述,以期指导临床实践。

Colorectal cancer(CRC)is one of the most common abdominal malignant tumors.Its incidence rate ranks third in the world and its mortality rate is second cause of cancer.Colorectal liver metastasis(CRLM)has remained a key and difficult point in the treatment of CRC and it is also a major prognostic factor.Currently resection is still optimal for curing CRLM.However,initial resection rate is merely 10%-20%.Thus it is imperative to convert a large number of CRLM patients with initial unresectable into resectable.For guiding clinical practices,recent advances of connotation,treatments and efficacy of CRLM conversion therapy were summarized.