重症新冠肺炎康复后继发性骨病的病因病机及防治方案探讨

Discussing Etiology and Treatment of Secondary Bone Disease in Convalescent Patients with Corona Virus Disease 2019

新型冠状病毒肺炎(COVID-19)的病原体、体内过程、中医病因病机辨证分析和诊疗方案都与重度急性呼吸综合征(SARS)有极大的相似之处。2003年SARS后大量重症患者康复后陆续出现严重的继发性骨病。基于温病传变的规律,从中西医结合角度,探讨重症COVID-19患者康复后继发性骨病的痰瘀互结、肾虚髓亏病因病机和激素干扰骨代谢平衡、干细胞损伤和ACE2介导的血管内皮性微循环障碍的分子细胞机制,并提供相应中西医结合防治方法与建议。

The pathogen, internal process, TCM etiology, pathogenesis analysis and diagnosis and treatment of corona virus disease 2019(COVID-19) plan are very similar to SARS. A large number of patients with SARS in 2003 had serious secondary bone disease after recovery. Due to the regularity of epidemic febrile disease transmission, from the point of view of the combination of TCM and western medicine, the article explored the molecular and cellular mechanisms of phlegm and blood stasis, pathogenesis of kidney deficiency and marrow deficiency, disturbance of bone metabolism by hormones, injury of stem cells and vascular endothelial microcirculatory disturbance mediated by ACE2, which may occur in severe COVID-19 patients after recovery, providing the corresponding integrated TCM and western medicine prevention and treatment methods and recommendations.