右美托咪定注射液联合利多卡因注射液用于腹腔镜全子宫切除术患者的临床研究

Clinical trial of dexmedetomidine injection combined with lidocaine injection in the treatment of patients undergoing laparoscopic hysterectomy

目的观察右美托咪定注射液联合利多卡因注射液用于腹腔镜全子宫切除术患者的临床疗效及安全性。方法将102例腹腔镜全子宫切除术患者随机分为对照A组34例、对照B组34例和试验组34例。3组患者麻醉诱导均采用丙泊酚和瑞芬太尼靶控输注。对照A组于麻醉诱导前10 min给予0.5μg·kg^(-1)右美托咪定静脉注射,麻醉诱导后,调整为0.4μg·kg^(-1)·h^(-1)持续泵注,关腹时停止给药;对照B组于麻醉诱导前10 min给予1.5 mg·kg^(-1)的2%利卡多因静脉注射,麻醉诱导后,调整为1.5 mg·kg^(-1)·h^(-1)持续泵注,关腹时停止给药;试验组于麻醉诱导前10 min给予0.5μg·kg^(-1)右美托咪定和1.5 mg·kg^(-1)的2%利卡多因静脉注射,麻醉诱导后,分别调整为0.4μg·kg^(-1)·h^(-1)和1.5 mg·kg^(-1)·h^(-1)持续泵注,关腹时停止给药。比较3组患者的胃肠功能恢复情况及药物不良反应的发生情况。结果术后,试验组、对照A组和对照B组的肠鸣音恢复时间分别为(21.36±3.54),(24.65±4.32)和(27.33±5.12)h,首次排气时间分别为(34.32±4.56),(37.45±5.20)和(42.24±6.35)h,两两比较,差异均有统计学意义(均P<0.05)。试验组、对照A组和对照B组的恶心发生率分别为41.48%,52.94%和61.76%,呕吐发生率分别为29.41%,41.18%和44.12%,两两比较,差异均无统计学意义(均P>0.05)。结论右美托咪定注射液联合利多卡因注射液用于腹腔镜全子宫切除术患者有助于促进早期胃肠功能的恢复,且不增加药物不良反应的发生率。

Objective To observe the clinical efficacy and safety of dexmedetomidine injection combined with lidocaine injection in the treatment of patients undergoing laparoscopic hysterectomy.Methods A total of 102 cases of laparoscopic hysterectomy patients were randomly divided into control A group,control B group and treatment group with 34 cases per group.The control A group was given intravenous injection of 0.5μg·kg^(-1) dexmedetomidine 10 min before induction of anesthesia,after induction of anesthesia,adjust to 0.4μg·kg^(-1)·h^(-1) for continuous pump injection,and stop the administration when the abdominal cavity was closed.The control B group was given an intravenous injection of 1.5 mg·kg^(-1) of 2%licardoine 10 min before induction of anesthesia,after induction of anesthesia,adjust to 1.5 mg·kg^(-1)·h^(-1) for continuous pump injection,and stop the administration when the abdominal cavity was closed.The treatment group was given intravenous injection of 0.5μg·kg^(-1) dexmedetomidine and 1.5 mg·kg^(-1)2%likadotin 10 min before induction of anesthesia,after induction of anesthesia,they were adjusted to 0.4μg·kg^(-1)·h^(-1) and 1.5 mg·kg^(-1)·h^(-1) for continuous pump injection,respectively,and the administration was stopped when the abdominal cavity was closed.The recovery of gastrointreatmentinal function and adverse drug reactions were compared among three groups.Results After operation,the recovery time of bowel sounds in the treatment group,control A group and control B group were(21.36±3.54),(24.65±4.32)and(27.33±5.12)h,the first exhaust time was(34.32±4.56),(37.45±5.20)and(42.24±6.35)h,the differences were statistically significant(all P<0.05).The incidences of nausea in the ttreatment,control A and control B groups were 41.48%,52.94%and 61.76%,the incidences of vomiting were 29.41%,41.18%and44.12%,the differences were not statistically significant(all P>0.05).Conclusion Dexmedetomidine injection combined with lidocaine injection helps to promote the early recovery of gastrointreatmentinal function in patients after laparoscopic hysterectomy,without increasing the incidence of adverse drug reactions.