侵袭性纤维瘤患者临床特点及预后因素分析

Analysis of clinical characteristics and prognostic factors of aggressive fibromatosis

目的分析中国人群侵袭性纤维瘤(AF)患者的临床特点,并探索患者首次治疗后的相关预后因素。方法用问卷调查的方法收集171例AF患者的临床信息,比较原发性和复发性AF患者的临床特点,并用单因素和多因素分析方法对性别、年龄、肿瘤部位、肿瘤大小等参数进行局部未复发生存率(LRFS)分析。结果首次治疗后原位复发的相关危险因素包括年龄[危险比(HR)=2.41,P<0.05]、肿瘤部位[胸膜/肠系膜/腹膜后膜(HR=2.90,P<0.05)、躯干(HR=2.31,P<0.05)和四肢(HR=1.93,P<0.05)]。结论年龄和肿瘤部位与AF原位复发的风险相关。

Objective To analyze the clinical characteristics of patients with aggressive fibromatosis(AF)in Chinese population and to explore the prognostic factors after the first treatment.Methods The clinical information of 171 patients with AF was collected by questionnaire survey.The clinical characteristics of primary and recurrent AF were compared.Gender,age,tumor location,tumor size and other parameters were analyzed by univariate and multivariate analysis for local recurrence-free survival(LRFS).Results Age[hazard ratio(HR):2.41,P<0.05]and tumor location[(tumors on pleura/mesentery/retroperitoneal membrane(HR=2.90,P<0.05),trunk(HR=2.31,P<0.05)and extremity(HR=1.93,P<0.05)]were the risk factors for local recurrence after the first treatment.Conclusion Age and tumor location are associated with the risk of local recurrence of AF.