新型高胆固醇血症治疗药物的研究现状

Research status of novel medication for hypercholesterolemia

高胆固醇症是心血管疾病的独立风险因素,严重威胁人们健康。经典的降胆固醇药物他汀类一般疗效显著,但对于家族性高胆固醇血症降脂作用有限,且他汀类存在多种药物不良反应,严重者可导致停药。为此,针对新靶点的新型高胆固醇血症治疗药物研发成为近年来的研究热点。本综述对近年来新型高胆固醇血症治疗药物的研究进展进行总结,以期为未来新型降胆固醇药物的精准用药提供参考。

Hypercholesterolemia was an independent risk factor for cardiovascular disease,which seriously threatened people’s health.Statins were classic cholesterol-lowering drugs which were generally effective.However,lipid-lowering effects of statins on familial hypercholesterolemia were limited.There were many adverse reactions of statins sometimes even led to drug withdrawal.For this reason,the development of new hypercholesterolemia treatment focusing on new targets had become the core of recent research.This review summarized the advances of new treatment to hypercholesterolemia in recent years and provided a reference for the precision medication of new lipid-lowering drugs in the future.