夏天无滴眼液联合消旋山莨菪碱滴眼液治疗儿童假性近视的疗效观察

Efficacy of Xiatianwu eye drops combined with raceanisodamine eye drops in the treatment of pseudomyopia in children

目的:探讨夏天无滴眼液联合消旋山莨菪碱滴眼液治疗儿童假性近视的疗效及安全性。方法:选取嘉兴市中医医院2018年6月至2019年6月收治的假性近视患儿8 000例为研究对象,采用随机数字表法将其分为对照组( n=4 000)及观察组( n=4 000),对照组采用消旋山莨菪碱滴眼液治疗,观察组在对照组的基础上联合夏天无滴眼液治疗,连续治疗30 d(1个疗程)后,分别采用国际E视力表、检影验光等检测两组患儿裸眼视力、屈光度,分别采用眼科A/B 超声诊断仪、非接触式眼压计等检测两组患儿眼轴长度、眼压,评估治疗效果,记录治疗期间不良反应发生情况。 结果:治疗30 d后,观察组裸眼视力为(0.88±0.33),高于对照组的(0.81±0.29)( t=10.077, P<0.001),屈光度为(-0.99±0.36)D,低于对照组的(-1.07±0.39)D( t=9.533, P<0.001);观察组总有效率为91.10%,高于对照组的88.18%(χ^(2)=18.422, P<0.001);两组患儿眼轴长度、眼压、不良反应发生率等差异均无统计学意义(均 P>0.05)。 结论:夏天无滴眼液联合消旋山莨菪碱滴眼液可改善假性近视患儿裸眼视力,提高治疗效果,且不增加不良反应发生率。

Objective To investigate the efficacy and safety of Xiatianwu eye drops in the treatment of pseudomyopia in children.Methods A total of 8000 children with pseudomyopia who received treatment in Jiaxing Hospital of Traditional Chinese Medicine between June 2018 and June 2019 were included in this study.They were randomly assigned to receive treatment with either raceanisodamine eye drops(control group,n=4000)or Xiatianwu eye drops combined with raceanisodamine eye drops(observation group,n=4000)for 30 successive days(1 treatment course).The uncorrected visual acuity and diopter in each group were detected by an'E'chart and optometry.Axial eye length and intraocular pressure in each group were measured using an ophthalmic A/B ultrasound scanner and a non-contact tonometer to assess the therapeutic effects.The incidence of adverse reactions during the treatment period was calculated.Results After 30 days of treatment,the uncorrected visual acuity in the observation group was significantly higher than that in the control group[(0.88±0.33)vs.(0.81±0.29),t=10.077,P<0.001].The diopter in the observation group was significantly lower than that in the control group[(-0.99±0.36)D vs.(-1.07±0.39)D,t=9.533,P<0.001].Total effective rate in the observation group was significantly higher than that in the control group(91.10%vs.88.18%,χ^(2)=18.422,P<0.001).There were no significant differences in the axial eye length,intraocular pressure and the incidence of adverse reactions between the two groups(all P>0.05).Conclusion Xiatianwu eye drops combined with raceanisodamine eye drops in the treatment of pseudomyopia in children can improve uncorrected visual acuity,increase therapeutic effects,and does not increase the incidence of adverse reactions.