益心通脉颗粒联合贝尼地平治疗冠心病心绞痛的临床研究

Clinical study on Yixin Tongmai Granules combined with benidipine in treatment of angina pectoris of coronary heart disease

目的探讨益心通脉颗粒联合贝尼地平治疗冠心病心绞痛的临床疗效。方法选取2018年11月—2020年11月在郑州市第一人民医院治疗的112例冠心病心绞痛患者,根据随机数字表法分为对照组(56例)和治疗组(56例)。对照组饭后口服盐酸贝尼地平片,1片/次,2次/d。治疗组在对照组基础上口服益心通脉颗粒,1包/次,3次/d。两组连续治疗14 d。观察两组患者临床疗效,比较治疗前后两组患者临床症状好转时间,心绞痛发作情况,血清炎性因子白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)和细胞间黏附分子1(ICAM-1)水平及不良反应情况。结果治疗后,治疗组患者总有效率明显高于对照组(P<0.05);治疗后,治疗组患者症状好转时间均早于对照组(P<0.05)。治疗后,两组患者心绞痛发作频率、每次发作持续时间明显降低(P<0.05),且治疗组患者均明显低于对照组(P<0.05)。治疗后,两组患者血清炎性因子IL-6、TNF-α、hs-CRP、ICAM-1水平均明显降低(P<0.05),且治疗组患者明显低于对照组(P<0.05)。治疗组患者不良反应发生率明显低于对照组(P<0.05)。结论益心通脉颗粒与贝尼地平联合治疗后,可有效改善冠心病心绞痛患者临床症状,降低血脂及炎性水平,且药物安全有效。

Objective To explore the clinical efficacy of Yixin Tongmai Granules combined with benidipine in treatment of angina pectoris of coronary heart disease.Methods Patients(112 cases)with angina pectoris of coronary heart disease in the First People’s Hospital of Zhengzhou from November 2018 to November 2020 were divided into control(56 cases)and treatment(56 cases)groups according to the table of random numbers.Patients in the control group were po administered with Benidipine Hydrochloride Tablets after meals,1 tablet/time,twice daily.Patients in the treatment group were po administered with Yixin Tongmai Granules on the basis of the control group,1 bag/time,three times daily.Patients in two groups were treated for 14 d.After treatment,the clinical efficacy was evaluated,and the improvement time of clinical symptoms,attack of angina pectoris,the serum inflammatory factor of IL-6,TNF-α,hs-CRP and ICAM-1 levels,and adverse reactions in two groups before and after treatment were compared.Results After treatment,the total clinical effective rate of the treatment group was significantly higher than that of the control group(P<0.05).After treatment,the improvement time of symptom in the treatment group was significantly earlier than that in the control group(P<0.05).After treatment,the frequency and duration of angina pectoris in the two groups were significantly decreased(P<0.05),and which in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,the levels of serum inflammatory factors IL-6,TNF-α,hs-CRP and ICAM-1 in the two groups were significantly decreased(P<0.05),and which in the treatment group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the treatment group was significantly lower than that in the control group(P<0.05).Conclusion The combined treatment of Yixin Tongmai Granules and benidipine can effectively improve the clinical symptoms of patients with angina pectoris of coronary heart disease,reduce blood lipids and inflammatory levels,and the drugs are safe and effective.