七味肝胆清颗粒联合头孢哌酮舒巴坦治疗慢性胆囊炎的临床研究

Clinical study on Qiwei Gandanqing Granules combined with cefoperazone and sulbactam in treatment of chronic cholecystitis

目的探讨七味肝胆清颗粒联合注射用头孢哌酮钠舒巴坦钠治疗慢性胆囊炎的临床疗效。方法选取2018年2月—2020年2月天津港口医院收治的184例慢性胆囊炎患者,按照随机数字表法将全部患者分为对照组和治疗组,每组各包括92例。对照组静脉滴注注射用头孢哌酮钠舒巴坦钠,4.0 g加入5%葡萄糖注射液100 mL中,2次/d。治疗组在对照组基础上温水冲服七味肝胆清颗粒,1.6 g/次,2次/d。两组患者连续治疗2周。观察两组患者的总有效率,比较两组患者主要症状消失时间、胆囊功能指标和血清炎症指标水平。结果治疗后,治疗组患者的总有效率为90.22%,对照组的总有效率为79.35%,组间比较差异有统计学意义(P<0.05)。治疗后,治疗组的退热时间、腹痛消失时间、恶心消失时间比对照组短,差异有统计学意义(P<0.05)。治疗后,两组的胆囊收缩率明显升高,胆囊壁厚度明显降低,差异有统计学意义(P<0.05);且治疗组的胆囊收缩率高于对照组,胆囊壁厚度低于对照组,差异有统计学意义(P<0.05)。治疗后,两组的C反应蛋白(CRP)、白细胞介素-6(IL-6)、降钙素原(PCT)水平显著降低,差异有统计学意义(P<0.05);且治疗组的CRP、IL-6、PCT水平比对照组低,差异有统计学意义(P<0.05)。结论七味肝胆清颗粒联合注射用头孢哌酮钠舒巴坦钠可提高慢性胆囊炎的临床疗效,改善临床症状,降低炎症反应,且安全性良好。

Objective To investigate the clinical efficacy of Qiwei Gandanqing Granules combined with Cefoperazone Sodium and Sulbactam Sodium for injection in treatment of chronic cholecystitis. Methods Patients(184 cases) with chronic cholecystitis in Tianjin Port Hospital from February 2018 to February 2020 were divided into control and treatment groups according to the method of random number table, and each group had 92 cases. Patients in the control group were iv administered with Cefoperazone Sodium and Sulbactam Sodium for injection, 4.0 g added into 5% glucose solution 100 mL, twice daily. Patients in the treatment group were po administered with Qiwei Gandanqing Granules on the basis of the control group, 1.6 g/time, twice daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and main symptoms disappear times, gallbladder function indexes, and serum inflammation indexes levels in two groups were compared. Results After treatment, the total effective rate of the treatment group was 90.22%, and that of the control group was 79.35%, and the difference was statistically significant(P < 0.05). After treatment, the antipyretic time, abdominal pain disappearance time, and nausea disappearance time of the treatment group were shorter than those of the control group, and the difference was statistically significant(P < 0.05). After treatment, the gallbladder contraction rate of two groups were significantly increased, but the gallbladder wall thickness of two groups were significantly decreased(P <0.05). And the gallbladder contraction rate of the treatment group was higher than that of the control group, but the gallbladder wall thickness of the treatment group was lower than that of the control group, and the difference was statistically significant(P < 0.05).After treatment, the levels of CRP, IL-6, and PCT in two groups were significantly decreased, and the difference was statistically significant(P < 0.05). And the levels of CRP, IL-6, and PCT in the treatment group were lower than those in the control group, and the difference was statistically significant(P < 0.05). Conclusion Qiwei Gandanqing Granules combined with Cefoperazone Sodium and Sulbactam Sodium for injection can improve the clinical efficacy of chronic cholecystitis, improve clinical symptoms, reduce inflammatory reaction, with good safety.