脊髓灰质炎疫苗免疫程序转换前后免疫效果比对分析

Comparative analysis of immunization effects before and after polio vaccine immunization schedule conversion

目的比较灭活脊髓灰质炎病毒疫苗(inactivated poliovirus vaccine,IPV)免疫程序转换前后江苏省健康儿童的脊灰抗体水平。方法分别于疫苗转换前后采集江苏省内5岁以下健康儿童血清样本200份,使用微量细胞中和试验法测定脊灰中和抗体,比较分析疫苗转换前后脊灰抗体阳性率及几何平均滴度(GMT)的差异。结果疫苗转换前脊灰抗体Ⅰ型阳性率为98.50%,Ⅲ型抗体阳性率为92.00%,GMT分别为:1∶100.43和1∶23.34;脊灰疫苗转换后脊灰抗体Ⅰ型阳性率为99.00%,Ⅲ型抗体阳性率为96.00%,Ⅰ型和Ⅲ型脊灰抗体GMT分别为:1∶213.04和1∶121.10。结论脊灰疫苗转换前后免疫效果存在差异,疫苗转换后人群抗体水平高于疫苗转换前,建议逐步增加IPV剂次以最终实现全程接种IPV。

Objective To compare the polio antibody level of healthy children in Jiangsu Province before and after the conversion of(inactivated poliovirus vaccine,IPV)immunization program.Methods 200 serum samples of healthy children under 5 years old in Jiangsu Province were collected before and after the vaccine conversion,and the neutralizing antibody against poliomyelitis was measured using the micro cell neutralization test.We compared the differences in the positive rate and geometric mean titer(GMT)of polio antibody before and after vaccine conversion.Results Before vaccine conversion,positive rates of antibody against poliovirus typeⅠandⅢwere 98.50%and 92.00%,with GMTs of 1∶100.43 and 1∶23.34,respectively.After the conversion,positive rates of polio antibody type I andⅢwere 99.00%and 96.00%,GMT were 1∶213.04 and 1∶121.10.Conclusions There is a difference in immunization effect before and after the polio vaccine conversion,and the antibody level of the population after vaccine conversion is higher than that before vaccine conversion.It is recommended to gradually increase the IPV dose in order to finally achieve the whole course of IPV inoculation.