Th9细胞参与溃疡性结肠炎发病的研究进展

Progress on the involvement of Th9 cells in the pathogenesis of ulcerative colitis

溃疡性结肠炎(ulcerative colitis,UC)是炎症性肠病(infammatory bowel disease,IBD)的主要类型之一,是一种慢性、非特异性、结肠炎症性疾病,易反复发作并需长期维持治疗,其临床特征包括:腹泻、体重丢失、腹痛、发热和便血以及癌变风险。目前认为UC的发病机制是由于环境因素作用于遗传易感个体,引起免疫系统异常激活,肠黏膜屏障破坏,导致结肠黏膜炎性改变,其中T细胞及其分泌的细胞因子参与免疫应答是UC发病机制研究领域的重要课题。Th9细胞是新近发现的T细胞亚群,其所分泌的IL-9已被证实参与多种自身免疫性疾病,现就Th9细胞的分化及其参与UC发病的机制加以综述。

Ulcerative colitis(UC)is one of the main types of inflammatory bowel disease(IBD).It is a chronic,nonspecific,and inflammatory disease of the colon that is prone to repeated attacks and requires long-term maintenance treatment.Its clinical features include:diarrhea,weight loss,abdominal pain,fever,blood in the stool and the risk of cancer.It is currently believed that the pathogenesis of UC is due to environmental factors acting on genetically susceptible individuals,causing abnormal activation of the immune system and destruction of the intestinal mucosal barrier,resulting in inflammatory changes of the colonic mucosa,in which T cells and cytokines secreted by them is the important topics in UC pathogenesis research.Th9 cells are a newly discovered subset of T cells.IL-9 secreted by it has been shown to be involved in a variety of autoimmune disease.Now we will review the differentiation of Th9 cells and the mechanisms involved in the pathogenesis of UC.