雷公藤治疗银屑病关节炎的新进展

New progress of Tr ipterygium Wilfordii in the treatment of psoriatic arthritis

银屑病关节炎是一种慢性炎症性关节病,和感染、免疫、遗传以及环境等多种因素有关.就临床研究而言,雷公藤单一用药,和西药或者是中药联合应用都可以取得非常明显的治疗效果,能够促进患者皮损症状以及关节症状的有效缓解.在作用机制层面,雷公藤的多靶点以及多成分作用会对B淋巴细胞、T淋巴细胞、树突状细胞以及巨噬细胞等免疫细胞的增殖和活化产生作用,能够对炎性细胞因子、黏附因子以及趋化因子分泌产生抑制作用,进而起到抗炎效果.临床需要对患者对病情进展以及生命体征变化对用药量进行控制和调整.

Psoriatic arthritis is a chronic inflammatory joint disease,which is related to many factors such as infection,immunity,genetics,and environment.As far as clinical research is concernerl,single merliration of Tripterygium wilfordii,combined with western medicine or traditional Chinese merlicine can achieves very obvious therapeutic effects,whic h ran promote ihe effective relief of patients'skin lesion symptoms and joint symptoms.At the level of the mechanism of action,ihe multi-target and multi-romponenl effects of Tripterygium wilfordii have an effect on the proliferation and activation of immune cells such as B lymphocytes,T lymphocytes,dendritic cells,and macrophages,and ran affect inflammatory cytokines,The serretion of adhesion factors and chemokines has an inhibitory effect,and thus has an anti inflammatory effect.It is clinically necessary to control and adjust the dosage of the patient's disease progression and vital signs changes.