不同交配型马尔尼菲篮状菌的抗真菌药物敏感性

Antifungal susceptibility profiles of Talaromyces marneffei with different mating types

马尔尼菲篮状菌是马尔尼菲篮状菌病的致病菌,具有不同交配型,且交配型分布具有地域差异。交配型是影响某些真菌药物敏感性的因素之一,但是否影响马尔尼菲篮状菌的药物敏感性不详。为了解马尔尼菲篮状菌交配型和其药物敏感性的关系,本研究检测了不同交配型马尔尼菲篮状菌对7种抗真菌药物的敏感性。结果显示,与MAT-1型马尔尼菲篮状菌相比,MAT-2型马尔尼菲篮状菌对伊曲康唑的敏感性较低,提示马尔尼菲篮状菌交配型可能与马尔尼菲唑类耐药相关。

Talaromyces marneffei is the causal agent of talaromycosis.It has been proved that T.marneffei has opposite mating types which showed geographical differences.Mating type plays a role in antifungal susceptibilities of fungi like Aspergillus fumigatus and Candida albicans,but whether it works in drug sensitivity of T.marneffei is still unknown.In this study,the susceptibilities of T.marneffei with different mating types(MAT-1 and MAT-2)against seven antifungals were tested.The data showed that T.marneffei strains with MAT-2 were less sensitive to itraconazole than those with MAT-1.The result suggests that mating type may play a role in antifungal susceptibility of T.marneffei.