摘要
目的探究体力活动对2型糖尿病遗传效应的修饰作用。方法利用中国双生子登记系统在11省/市募集的12107对≥30岁同性别双生子,拟合单变量交互作用模型计算体力活动对2型糖尿病遗传效应的修饰作用。结果调整年龄、性别后,2型糖尿病的遗传度为0.56(0.31~0.84)。体力活动达标可降低2型糖尿病的遗传效应。体力活动达标双生子2型糖尿病的遗传度为0.46(0.06~0.88),低于相同模型中体力活动未达标双生子2型糖尿病的遗传度[0.68(0.36~0.94)]。结论2型糖尿病属于中度遗传疾病,体力活动可修饰2型糖尿病的遗传效应。
Objective To explore the modification effect of physical activity on the genetic effects of type 2 diabetes mellitus(T2DM).Methods The univariate moderation model was fitted to calculate the modifying effect of physical activity on the genetic effects of T2DM based on the data of 12107 pairs of same gender twins aged 30 years and older enrolled by the Chinese National Twin Registry in 11 provinces/cities in China.Results After adjusting for age and gender,the heritability of T2DM was 0.56(0.31-0.84).Qualified physical activity could attenuate the genetic effects of T2DM.The heritability of T2DM in twin pairs with qualified physical activity was 0.46(0.06-0.88),which was lower than that in twin pairs without qualified physical activity during the same model[0.68(0.36-0.94)].Conclusion T2DM is a moderate genetic disease,physical activity can modify the genetic effects of T2DM.
作者
陈松建
高文静
吕筠
余灿清
王胜锋
黄涛
孙点剑一
廖春晓
逄增昌
俞敏
汪华
吴先萍
董忠
吴凡
江国虹
王晓节
刘彧
邓健
陆林
曹卫华
李立明
Chen Songjian;Gao Wenjing;Lyu Jun;Yu Canqing;Wang Shengfeng;Huang Tao;Sun Dianjianyi;Liao Chunxiao;Pang Zengchang;Yu Min;Wang Hua;Wu Xianping;Dong Zhong;Wu Fan;Jiang Guohong;Wang Xiaojie;Liu Yu;Deng Jian;Lu Lin;Cao Weihua;Li Liming(Department of Epidemiology and Biostatistics,School of Public Health,Peking University Health Science Center,Beijing 100191,China;Qingdao Municipal Center for Disease Control and Prevention,Qingdao 266033,China;Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310051,China;Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210008,China;Sichuan Center for Disease Control and Prevention,Chengdu 610041,China;Beijing Center for Disease Prevention and Control,Beijing 100013,China;Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China;Tianjin Centers for Disease Control and Prevention,Tianjin 300011,China;Qinghai Center for Disease Prevention and Control,Xining 810007,China;Heilongjiang Provincial Center for Disease Control and Prevention,Harbin 150030,China;Handan Center for Disease Control and Prevention,Handan 056001,China;Yunnan Center for Disease Control and Prevention,Kunming 650037,China)
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2021年第7期1167-1173,共7页
Chinese Journal of Epidemiology
基金
公益性行业科研专项(201502006,201002007)
国家自然科学基金(81711530051)。
关键词
糖尿病
2型
双生子研究
基因环境交互作用
Diabetes mellitus,type 2
Twin study
Gene-environment interaction
