出生体重对成年期慢性病患病风险及血尿酸的影响研究

Study of influence of birth weight on risk of chronic diseases and blood uric acid in adulthood

目的探索出生体重对成年期罹患高血压、糖尿病等慢性病的患病风险,并研究出生体重与血尿酸的关系。方法根据中国成年人慢性病与营养监测方案,在天津市河西、南开、红桥、武清、津南、宝坻、蓟州区共计调查1131名成年人,收集其出生体重、血压等数据,并采集空腹静脉血检测血尿酸、血糖和血脂等。描述调查人群出生体重状况分布,并分析出生体重对其成年期罹患高血压、糖尿病等慢性病风险及与血尿酸的关系。结果天津市调查人群平均出生体重为3.37 kg,男性高于女性;无论是超重/肥胖、高血压还是糖尿病,正常出生体重者成年期患病率最低,经单因素logistic回归分析,校正年龄、性别、吸烟、饮酒后发现,与正常出生体重者相比,低出生体重与成年期罹患糖尿病(OR=2.91,95%CI:1.46~5.76)、血脂异常(OR=1.79,95%CI:1.01~3.19)关联较强,巨大儿与成年期罹患超重/肥胖关联较强(OR=1.47,95%CI:1.08~2.01);不同出生体重的血尿酸差异无统计学意义。结论天津市调查人群低出生体重与其成年期糖尿病、血脂异常患病风险关联较大,巨大儿与其成年期超重/肥胖患病风险关联较大。

Objective To understand the influence of birth weight on the risk of chronic diseases,such as hypertension and diabetes,and the relationship between birth weight and serum uric acid in adulthood.Methods According to the Chinese Adult Chronic Disease and Nutrition Surveillance Program,a total of 1131 residents aged 18 years and above were enrolled from Hexi,Nankai,Hongqiao,Wuqing,Jinnan,Baodi and Jizhou districts of Tianjin.The data of birth weight and blood pressure of the residents were collected,and fasting venous blood samples were collected from them to detect uric acid,blood glucose and blood lipids levels.The distribution of birth weight of the surveyed population was described,and the relationship between birth weight and chronic diseases,such as hypertension and diabetes,and the blood uric acid level in adulthood were analyzed.Results The average birth weight of the surveyed population in Tianjin was 3.37 kg,which was higher in males than in females.No matter overweight/obesity,hypertension or diabetes,the prevalence rate of normal birth weight was the lowest in adulthood.After univariate logistic regression analysis and adjusting for age,sex,smoking and drinking status,it was found that compared with normal birth weight,low birth weight had a stronger correlation with diabetes(OR=2.91,95%CI:1.46-5.76)and dyslipidemia(OR=1.79,95%CI:1.01-3.19)in adulthood.Macrosomia was strongly associated with overweight/obesity in adulthood(OR=1.47,95%CI:1.08-2.01).There was no significant difference in serum uric acid level among the residents with different birth weights.Conclusions The low birth weight of the surveyed population in Tianjin was closely related to the risk of diabetes and dyslipidemia in adulthood,and the macrosomia was closely related to the risk of overweight/obesity in adulthood.