重离子束联合免疫疗法治疗恶性肿瘤的基础研究进展

Basic research progress on the combination of heavy ion beam and immunotherapy in the treatment of malignant neoplasm

近年来重离子束因其放射物理学及生物学特性在恶性肿瘤放疗方面受到高度关注。重离子治疗已经在临床上取得了一定成果,局部肿瘤控制率高是其一大优势,但在多数恶性肿瘤治疗中转移病灶的控制仍然至关重要。常规放疗与免疫疗法联合应用的临床研究提示两者联合不仅可以控制原发病灶,还有可能减少或完全消除远处转移性病灶。而高能量线性传递射线尤其是重离子束在联合免疫治疗方面可能具有更强的潜力,故本文重点综述了重离子束调节抗肿瘤免疫效应及与免疫疗法联合应用的基础研究进展。

In recent years,heavy ion beams have received great attention in the field of malignant tumor radiotherapy due to their radiation physics and biological characteristics.The high rate of local tumor control is one of its advantages,but the control rate of metastatic lesions is still crucial in the treatment of most malignant tumors.Clinical studies on the combined conventional radiotherapy and immunotherapy suggest that the combination of the two can not only control the primary lesions,but may also reduce or completely eliminate distant metastatic lesions.High linear energy transfer radiation,especially heavy ion beams,may have stronger potential in combined immunotherapy.Therefore,this article focuses on the basic research progress of heavy ion beams regulating anti-tumor immune effects and their combined application with immunotherapy.