T细胞在新月体肾炎中作用的研究进展

Updates on the role of T lymphocytes in crescentic glomerulonephritis

新月体的形成是肾功能急剧恶化的典型病理改变。T细胞参与了新月体的形成和新月体肾炎的病理进展。T细胞亚群中CD4^(+)和CD8^(+)细胞,以及T细胞共刺激因子以不同的方式介导免疫应答,参与了新月体的发生、发展和纤维化,亦或者延缓其恶化。该文综述T细胞在新月体形成和发展的作用机制,以期为临床治疗新月体肾炎提供新靶点。

The formation of crescent is a typical pathological change characterized by a rapid deterioration of renal function.T lymphocytes are involved in the formation of crescent and the pathological progression of crescent nephritis.CD4^(+) and CD8^(+) cells in T lymphocyte subsets,and T cell costimulatory factors mediate immune responses in different ways.They participate in the occurrence,development and fibrosis of crescent,or delay their deterioration.In order to provide a new target for clinical treatment of crescent nephritis,we review the mechanism of T lymphocytes in the formation and development of crescentic body.