香菇多糖辅助治疗非小细胞肺癌对患者免疫功能的影响

The Effect of Lentinan in the Treatment of Non-small Cell Lung Cancer on the Immune Function of Patients

目的分析香菇多糖注射液联合化疗治疗非小细胞肺癌(nonsmall cell lung carcinoma,NSCLC)的效果以及对免疫功能的影响。方法选择我院2017年12月—2019年12月的90例非小细胞肺癌作为研究对象,采用隐匿数字随机法分为两组,对照组45例采用顺铂+吉西他滨(gemcitabine,GP)常规化疗,研究组45例在此基础上联合香菇多糖注射液治疗,治疗前、后抽取外周血检测两组免疫功能指标,比较两组有效率、疾病控制率。结果研究组客观缓解率(objective response rate,ORR)、疾病控制率(disease control rate,DCR)分别为66.67%、88.89%,高于对照组的44.44%、77.78%,差异具有统计学意义(P <0.05)。研究组疗程结束后KPS评分高于对照组,中位PFS、中位OS长于对照组,差异具有统计学意义(P <0.05)。疗程结束后研究组CD3+、CD4+、NK细胞构成、CD4+/CD8+比值均高于对照组,CD8+低于对照组,差异具有统计学意义(P <0.05)。结论香菇多糖注射液联合化疗可提高非小细胞肺癌的疗效,并可在一定程度上保护患者的免疫功能。

Objective To analyze the effect of lentinan injection combined with chemotherapy in the treatment of non-small cell lung cancer(nonsmall-cell carcinoma, NSCLC) and its influence on immune function. Methods From December 2017 to December 2019, 90 cases of non-small cell lung cancer in our hospital were selected as the research object, and they were divided into two groups by the concealed number random method. The control group 45 cases received cisplatin + gemcitabine(gemcitabine, GP) conventional chemotherapy. Observation group of 45 patients were treated with lentinan injection on this basis. Peripheral blood was drawn before and after treatment to test the immune function indexes of the two groups, and the effective rate and disease control rate of the two groups were compared. Results The objective response rate(ORR) and disease control rate(DCR) of the study group were 66.67% and 88.89%, respectively. which were higher than 44.44% and 77.78% of the control group. The difference was statistically significant(P < 0.05). The KPS score of the study group was higher than that of the control group after the treatment course, and the median PFS and median OS were longer than those of the control group. The difference was statistically significant(P < 0.05). After the course of treatment, the CD3+, CD4+, NK cell composition, and CD4+/CD8+ ratio of the study group were higher than those of the control group, and the CD8+ was lower than the control group. The difference was statistically significant(P < 0.05). Conclusion Lentinan injection combined with chemotherapy can improve the curative effect of non-small cell lung cancer and protect the patient’s immune function to a certain extent.