刺激响应聚合物微针在经皮给药中的应用

Stimuli-Responsive Polymeric Microneedles for Transdermal Drug Delivery

聚合物微针自身具有良好的机械性能和优异的生物相容性,能以微创的方式刺穿皮肤角质层,实现药物的高效经皮吸收,从而有效治疗各种疾病,如糖尿病、癌症、肥胖以及眼部疾病等。如何调控聚合物微针中负载药物的释放行为,是微针经皮给药需要关注的核心要素。刺激响应释放聚合物微针作为一种新兴的按需给药技术,能根据外界环境条件或自身生理环境变化实现药物的局部精确释放,是当前经皮给药领域的研究热点之一。目前,刺激响应聚合物微针的研究主要集中在光响应、pH响应、酶响应以及葡萄糖响应聚合物微针方面。本文将从微针在不同疾病中的应用,详细综述刺激响应聚合物微针的研究进展,并对这一领域的未来发展进行展望。

The polymeric microneedles,which has excellent mechanical property and biocompatibility,can pierce the stratum corneum in a minimally-invasive manner and result in efficient transdermal delivery of drugs.Thereby the polymeric microneedles can effectively treat various diseases,such as diabetes,cancer,obesity,eye diseases and so on.How to control the release behavior of the loaded drug is the key point in the polymeric microneedles.Stimuli-responsive polymeric microneedles,as an emerging technology for on-demand drug delivery,can achieve topical accurate release of drugs according to the change of the external environment or the physiological signal in cutaneous environment,making it the current research hotspot in transdermal drug delivery.At present,stimuli-responsive polymeric microneedles are always designed based on light response,pH response,enzyme response and glucose response.This paper reviews the recent researches of the stimuliresponsive polymeric microneedles in detail.Challenges and prospects of stimuli-responsive polymeric microneedles are also discussed.