产气荚膜梭菌ε毒素研究进展

Progress on Clostridium perfringens ε-toxin

产气荚膜梭菌是一种重要的人畜共患细菌性传染病病原,在自然界中分布极广,一定条件下可引起多种疾病。该菌常通过其外毒素危害人和动物机体,所产毒素主要有α、β、ε和ι4种外毒素。根据毒素产生的情况,将产气荚膜梭菌分为A、B、C、D、E、F和G 7个型。ε毒素毒力最强,主要由B型和D型菌分泌。论文通过致病机理、病理变化、流行特点及相关疫苗研究方面对产气荚膜梭菌ε毒素研究进展进行综述,以期为产气荚膜梭菌病的防控提供参考。

Clostridium perfringens is an important zoonotic bacterial infectious pathogen.It is widely distributed in nature and can cause many diseases under certain conditions.C.perfringens often endangers humans and animals through its exotoxin, and the toxins produced mainly include α,β,ε and ι four types.According to the production of those four toxins, C.perfringens is divided into seven types: A,B,C,D,E,F,and G.ε-toxin is the most virulent and is mainly secreted by type B and D bacteria.The paper reviewed the latest research progress on C.perfringens ε-toxin through four aspects of pathogenic mechanism, pathological lesions, epidemic characteristics and related vaccines, in order to provide a theoretical basis for the prevention and control of C.perfringens disease.