摘要
The liver is one of the most common sites for cancer metastasis,which leads to secondary hepatic malignancies.Almost all solid tumors,such as melanoma,breast cancer,gastric cancer,colorectal cancer,and lung cancer,metastasize to the liver.1,2 Overall,20–25%of colorectal cancer patients may eventually develop liver metastases(also known as CRC liver metastases).3 In addition to some common occurrence of liver metastasis in colorectal cancer,the liver is also one of the predominant metastatic sites for melanoma,including cutaneous and ocular melanoma.2 Thus,an understanding of the mechanism of liver metastasis is urgently needed for the development of novel strategies to prolong overall survival for patients with liver metastases.
基金
supported by a grant from the Ministry of Science and Technology(MOST 108-2314-B-194-003-MY2).
