基于文献计量学的POLE/POLD1突变在结直肠癌中研究的可视化分析

Visual analysis of research on POLE/POLD1 mutation in colorectal cancer:based on bibliometrics

目的基于文献计量学方法,可视化分析DNA聚合酶ε/DNA聚合酶δ1(POLE/POLD1)突变在结直肠癌中的研究现状,并进一步探索其当前热点、展望未来发展趋势。方法以Web of Science数据库为数据来源,检索建库以来至2020年9月30年间已发表的相关文献,利用VOSviewer 1.6.11和CiteSpace 5.7软件对纳入已发表文献中的研究国家/机构分布情况、作者和关键词进行分析,并对关键词进行聚类分析、时间演化分析和Burst分析,绘制对应的可视化图谱并进行解析。结果共纳入299篇已发表的文献。文献计量学分析结果显示,近年来POLE/POLD1突变在结直肠癌诊疗中的应用研究稳步发展,2012年以后,年发表的研究文献数量开始明显增加;载文量最多的杂志是Familial Cancer和Proceedings of the National Academy of Sciences of the United States of America。发文量最高的作者是Tomlinson I。对发表文献所属国家和地区的分析结果显示,美国是该领域研究的主要国家,对发文量贡献最大;对研究者所在学术机构/大学分析后可知,英国牛津大学是发文量最多的研究大学/机构。关键词的聚类分析及时间演化分析结果表明,有关POLE/POLD1突变的研究热点集中在该基因突变对免疫治疗的影响。Burst分析结果显示,当前该领域已发表的研究从发表后2年开始被高引用并持续至今。结论 POLE/POLD1在结直肠癌中的突变无疑是当前研究的热点领域,其中肿瘤免疫治疗是该领域研究的焦点。

Objective Based on the method of bibliometrics,to visually analyze the current research status of DNA polymerase epsilon catalytic/DNA polymerase delta catalytic subunit(POLE/POLD1)mutations in colorectal cancer,and further to explore its current hot spots and to look forward to future development trends.Methods Used the Web of Science database as the data source to retrieve the published related literatures in the 30 years from the establishment of the database to September 2020,and used VOSviewer 1.6.11 and CiteSpace 5.7 software to analyze the the distribution of research countries/institutions,authors and keywords in the included published literatures.And to perform cluster analysis,time evolution analysis and Burst analysis on keywords,draw corresponding visual maps and analyzed them.Results A total of 299 published articles were included.Bibliometric analysis showed that the application of POLE/POLD1 mutations in colorectal cancer had developed steadily in recent years.After 2012,the number of published studies had increased significantly;the journals with the most articles were Familial Cancer and Proceedings of the National Academy of Sciences of the United States of America.The author with the highest number of articles was Tomlinson I.The analysis of countries and regions showed that the United States was the main country for research in this field and had contributed the most to the amount of publications.After analyzed the academic institutions/universities where the researchers were located,it could be seen that the University of Oxford was the research university/institution with the most publications.Keyword cluster analysis and time evolution analysis showed that the research hotspots in this field focus on the impact of this gene mutation on immunotherapy.Burst analysis showed that the current published research in this field started two years after publication and continues to be highly cited.Conclusions POLE/POLD1 mutation has undoubtedly become a hot area of current research in colorectal cancer research.Among them,tumor immunotherapy is the focus of research in this field.