循环肿瘤DNA在乳腺癌早期诊断中的临床应用进展

Advances in clinical applications of circulating tumor DNA for early diagnosis of breast cancer

目的探讨循环肿瘤DNA(circulating tumor DNA,ctDNA)在乳腺癌早期诊断中的临床应用进展。方法检索有关ctDNA在乳腺癌早期诊断中的临床应用进展的最新文献并作综述。结果 ctDNA是一种有前途、有潜力的生物检测指标,可以动态地反映肿瘤基因组全貌,因其具有创伤小、取材方便、可以实时监测等优势,广泛应用于多种肿瘤的早期诊断、治疗效果的监测与预后的评估,其在乳腺癌中的作用近年来也愈发受到关注。结论早期诊断对于提高乳腺癌患者的生存率至关重要,ctDNA的检测在乳腺癌的早期诊断及复发转移的早期发现中发挥着重要的作用。

Objective To explore advances in clinical applications of circulating tumor DNA(ctDNA)for early diagnosis of breast cancer.Method Reviewed on the latest literatures about studies of advances in clinical applications of ctDNA for early diagnosis of breast cancer.Results ctDNA was a cell-free DNA generated by tumor cells that contained tumor-associated mutations and could dynamically reflect the entire picture of the tumor genome.It was a very important potential tumor biomarker.ctDNA had been widely used in a variety of tumors for early diagnosis,curative effect assessment,and prognosis evaluation due to its advantages such as small trauma and real-time monitoring,and its role in breast cancer had attracted more and more attention.Conclusion Early diagnosis is critical to improve the breast cancer patients’overall survival rate and ctDNA plays an important role in early diagnosis and early detection of recurrence and metastasis of breast cancer.