他克莫司在皮肤科的临床应用

Clinical Application of Tacrolimus in Dermatology

他克莫司具有较强的免疫抑制作用,此作用无论在体外还是在体内试验都较环孢素强数十倍到数百倍。他克莫司最初是用于预防和治疗肾移植和骨髓移植后的排斥反应,但在用药的过程中发现该药对某些接受器官移植患者的皮肤病产生了良好的作用。后来,他克莫司被发现对多种免疫相关性疾病有效。因此,利用其相对分子质量小而有较好的透皮性这一特点,将其发展为外用制剂,在皮肤科得到广泛应用。本文就他克莫司在皮肤科的临床应用做一总结。

Tacrolimus has a strong immunosuppressive effect,which is tens to hundreds of times stronger than cyclosporine in vitro or in vivo.Tacrolimus was originally used for the prevention and treatment of rejection after kidney and bone marrow transplants,but during the course of treatment it was found to have a favorable effect on the skin disease of some organ transplant patients.Later,it was found to be effective for a variety of immune・related diseases.Due to its relatively small molecular weight,good transdermal absorption and low drug concentration,tacrolimus has been widely used in dermatology.This article summarizes the clinical application of tacrolimus in dermatology.