羟氯喹在皮肤科应用的系统回顾

Systematic Review:Application of Hydroxychloroquine in Dermatology

羟氯喹是氯喹的羟基衍生物,具有抗炎、抗疟、免疫调节、抗病毒等药理作用。羟氯喹在皮肤科领域的应用已有60多年的历史,对某些结缔组织病、炎症性皮肤病和光线性皮肤病有较好的疗效。尽管羟氯喹疗效显著,但羟氯喹有潜在的不良反应,包括消化道症状、皮肤反应、罕见贫血、肌病、心脏毒性、粒细胞缺乏症、肝脏毒性和视网膜病变。本文就羟氯喹的药代动力学、作用机制、皮肤科的临床应用、药物剂量及不良反应进行系统回顾。

Hydroxychloroquine is hydroxylamine derivative of chloroquine.Hydroxychloroquine has anti-inflammatory,immunomodulatory,and antivirus ability.Hydroxychloroquine has been used in the dermatology for over 60 years.Hydroxychloroquine has good response on some connective tissue disease,inflammatory dermatosis and photosensitive dermatosis.Despite the good affect of hydroxychloroquine,potential adverse effects include gastrointestinal symptoms,cutaneous reactions,rarely anemia,myopathy,cardiotoxicity,agranulocytosis,hepatotoxicity and retinopathy.A systematic review of this drug including pharmacokinetics,mechanism,dosage,adverse reaction and clinical application in dermatology are reviewed.