来氟米特在皮肤科应用的系统回顾

A Systematic Review of Leflunomide in Dermatology

来氟米特是一种异嚦唑衍生物,主要通过抑制二氢乳清酸脱氢酶发挥作用。二氢乳清酸脱氢酶为淋巴细胞克隆扩增时嘧啶从头合成途径的关键酶。来氟米特在皮肤科主要用于治疗银屑病、银屑病性关节炎、特应性皮炎、系统性红斑狼疮、肉芽肿性血管炎、原发性干燥综合征、大疱性类天疱疮、皮肌炎、结节病和系统性硬皮病等。本文就来氟米特的药代动力学、作用机制、在皮肤科的临床应用、药物剂量及不良反应进行系统回顾。

Leflunomide is an isoxazole derivative that acts mainly by inhibiting dihydroorotic acid dehydrogenase.Dihydroorolate dehydrogenase is a key enzyme in the de novo pyrimidine synthesis pathway during lymphocyte clonal expansion.Leflunomide is mainly used in dermatology to treat psoriasis,psoriatic arthritis,atopic dermatitis,systemic lupus erythematosus,granulomatous vasculitis,primary Sjogren's syndrome,pemphigoid pemphigoid,dennatomyositis,sarcoidosis,and systemic scleroderma.A systematic review of the leflu no mi de on pharmacokinetics,mechanism,the application in dermatology,dosage and adverse reaction is reported in this paper.