基于数据挖掘的中医药治疗多囊卵巢综合征的用药规律分析

Analysis on medication rules of traditional Chinese medicine in the treatment of polycystic ovary syndrome based on data mining

目的基于数据挖掘探析中医药治疗多囊卵巢综合征的用药特点及组方规律。方法检索2010年1月至2020年3月期间符合纳入标准的多囊卵巢综合征中医类文献,建立中药数据库,利用数据挖掘技术对中药数据进行频次统计、性味归经及药物功效分类分析、关联规则分析、系统聚类分析等。结果共纳入文献232篇,医案、处方共计702例,涉及303味中药,药物使用总频次达10490次。单味中药使用频次位于前10位的分别是当归、菟丝子、茯苓、香附、川芎、白术、熟地黄、甘草、丹参、白芍;中药功效分类分析中频次前2位为补虚药、活血化瘀药,其次依次是清热药、利水渗湿药及理气药;中药性味及归经分析显示常用药物以温、平、甘、苦为主、多归肝(胆)经、脾(胃)经、肾(膀胱)经。常用药对有当归-川芎、当归-熟地黄、当归-白芍、茯苓-陈皮、菟丝子-淫羊藿等。结论中医药治疗多囊卵巢综合征多从补肾活血通经、健脾化痰祛湿、理气养血调肝三方面入手,用药以补虚药和活血化瘀药为主,寓消于补,气血兼顾,攻补兼施,肾肝脾三脏同调以达冲任调畅、气血和调之效。

Objective To investigate the medication features and prescription rule of traditional Chinese medicine(TCM)treatment of polycystic ovary syndrome based on data mining.Methods Related articles on TCM treatment of polycystic ovary syndrome which were published from January 2010 to March 2020 and met the inclusion criteria were searched to establish a TCM database,and the data mining technique was used to perform a statistical analysis of frequency,classification analyses of the nature,taste,meridian tropism,and function of TCM drugs,and association rule analysis,and a hierarchical cluster analysis.Results A total of 232 articles were included,with 702 medical records and prescriptions in total,which involved 303 TCM herbs with a total frequency of 10490 times.The top 10 most frequently used TCM herbs were Angelica sinensis,China dodder seed,Poria cocos,Rhizoma Cyperi,Rhizoma Chuanxiong,Atractylodes macrocephala Koidz,prepared Radix Rehmanniae,Radix Glycyrrhizae,Salvia miltiorrhiza,and Radix Paeoniae Alba.The classification analysis of TCM function showed that deficiency-tonifying herbs and blood-activating and stasis-resolving herbs were the most frequently used herbs,followed by heat-clearing herbs,diuresis-inducing and dampness-draining herbs,and Qi-regulating herbs.The analysis of the nature,taste,and meridian tropism of TCM herbs showed that most of the commonly used herbs were warm,neural,sweet,and bitter in nature,and most of them had the meridian tropism of the liver(gallbladder)meridian,the spleen(stomach)meridian,and the kidney(bladder)meridian.Commonly used drug combinations included Angelica sinensis-Rhizoma Chuanxiong,Angelica sinensis-prepared Radix Rehmanniae,Angelica sinensis-Radix Paeoniae Alba,Poria cocos-tangerine peel,and China dodder seed-Herba Epimedii.Conclusion TCM treatment of polycystic ovary syndrome is mainly achieved by tonifying the kidney+activating blood circulation+dredging collaterals,invigorating the spleen+removing phlegm+eliminating dampness,and regulating Qi+nourishing the blood+regulating the liver.Deficiency-tonifying herbs and blood-activating and stasis-resolving herbs are commonly used for treatment to give consideration to both Qi and blood,perform tonification and purgation in combination,and simultaneously regulate the kidney,the liver,and the spleen,thus achieving the effect of activating and harmonizing the thoroughfare and conception vessels and regulating Qi-blood.