早期偏头痛患者脑网络度中心度的静息态fMRI研究

Degree centrality of brain network in patients with early migraine:a resting-state functional magnetic resonance imaging study

目的:采用静息态功能磁共振(resting-state functional magnetic resonance imaging,rsfMRI)探究早期偏头痛患者脑网络度中心度相较于健康人群是否存在异常。方法:对重庆市潼南区人民医院44例早期偏头痛患者及45名健康对照者(正常对照组)行rsfMRI扫描,所得数据利用DPARSFA软件预处理,并基于图论理论分析比较早期偏头痛患者和健康人群度中心度(degree centrality,DC)值差异,通过斯皮尔曼相关分析差异脑区DC值与简易智力状态检查量表(mini-mental state examination,MMSE)评分、汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)评分和汉密尔顿抑郁量表(Hamilton depression scale,HAMD)评分的相关性。结果:早期偏头痛组和健康对照组进行全脑网络节点度中心度比较发现,在丘脑、颞上回、内侧额叶脑回、额叶、边缘叶、中央后回、中央前回、旁中央小叶脑区存在统计学差异(P<0.05,Cluster>20,TFCE校正,置换检验次数为5000),但DC值与临床评分无相关性(P>0.05)。结论:早期偏头痛患者脑网络度中心度改变的脑区主要位于痛觉辨别处理区,为进一步探究偏头痛的病理学和神经生理学机制提供了新的发现。

Objective:To investigate the abnormality of degree centrality of brain network in patients with early migraine compared with healthy subjects using resting-state functional magnetic resonance imaging(f MRI).Methods:A total of 44 patients with early migraine and 45 healthy controls were included,and the resting-state f MRI scanning for each subject was performed.The MRI data were pre-processed using DPARSFA software.The degree centrality(DC)based on graph theory analysis was calculated for both patients with early migraine and healthy controls.The comparison was performed by independent-sample t-test,and the spearman correlation analysis was used to evaluate the correlation between DC value of significant brain areas and the mini-mental state examination(MMSE),Hamilton anxiety scale(HAMA)and Hamilton depression scale(HAMD)scores.Results:For the patients with early migraine,the DC values in the thalamus,the superior temporal gyrus,the medial frontal gyrus,the frontal lobe,the limbic lobe,the posterior central gyrus,the anterior central gyrus and the paracentral lobule were significantly different compared to the healthy subjects(P<0.05,the Cluster>20,TFCE,permutation times>5000),but there was no correlation between the DC values and clinical scores(P>0.05).Conclusion:The changes of DC values in patients with early migraine are mainly located in the area of pain recognition and processing,which provides a new discovery for further exploring the pathological and neurophysiological mechanisms of migraine.