介孔碳纳米球在肿瘤诊疗中的研究进展

Progress in the Diagnosis and Treatment of Cancer Based on Mesoporous Carbon Nanospheres

介孔碳纳米球作为三维碳基纳米材料,具有较好的生物相容性、高比表面积和可控介孔结构,成为药物、生物染料、光敏剂等的优良载体。近年来介孔碳纳米球的合成工艺和功能研究取得了重大进展,在肿瘤成像、药物的靶向递送和响应性释放、光学治疗、声动力学治疗和生物催化领域表现出应用潜力。本文对近期介孔碳纳米球在合成和肿瘤诊疗领域的发展进行综述,为介孔碳纳米球在肿瘤诊疗中的研究提供借鉴。

As a kind of three-dimensional carbon materials,mesoporous carbon nanospheres(MCN)perform high biocompatibility,high specific surface area and controllable particle and pore size,and therefore become good carriers for delivering drugs,cell dyes,photosensitizers and so on for biomedical usage.Recently,there is a big progress on its synthetic methodologies and theranostic functions,thus showing great potential in the application of bioimaging,targeted drug delivery,controllable drug release,phototherapy,sonodynamic therapy and biocatalysis.Studies on synthetic methodologies and diagnosis and treatment of cancer based on mesoporous carbon nanospheres are reviewed to provide support for the further studies.