铱催化的(杂)芳烃远端区域选择性C—H硼化反应的最新进展

Recent Progress in Iridium-Catalyzed Remote Regioselective C—H Borylation of(Hetero)Arenes

(杂)芳基硼酸及其衍生物在合成化学、材料科学和药物化学领域具有广泛的用途,因此,其合成方法研究一直备受关注.铱催化的C—H硼化反应是合成这类化合物最为有效的途径之一,然而,由于反应机理的限制,区域选择性可控的C—H硼化是铱催化体系的一大挑战,同时也是该领域的一个重要发展方向.系统介绍了最近几年铱催化的芳烃远端硼氢化反应的最新进展.

(Hetero)Aryl boronic acids and their derivatives have been widely used in synthetic chemistry,material sciences,and drug discovery.Accordingly,the development of novel synthetic methods towards these structures has received a great deal of attention.In particular,Ir-catalyzed C—H borylation represents one of the most efficient methods.Due to the restriction of the reaction mechanism,regioselective controllable C—H borylation of Ir catalysis is a formidable challenge,and it is also an important development direction in this area.In this review,the recent progress in Ir-catalyzed remote selective C—H borylation of arenes is systematically discussed.