手性单齿亚磷酸酯配体在不对称氢化反应中的研究进展

Advancement of Chiral Monodentate Phosphite Ligands in Asymmetric Hydrogenation

进入21世纪以来,手性单磷配体特别是手性亚磷酸酯和亚磷酰胺类单磷配体的研究引起了国内外的广泛关注,这些单齿磷配体的合成简单、原料价格低廉、性质稳定,同时在不对称催化反应中表现出高活性和对映选择性.对近二十年来不对称催化氢化领域里手性亚磷酸酯配体的发展历程进行了综述,介绍了亚膦酸酯(Phosphonites)、亚磷酸酯(Phosphites)和亚磷酰胺(Phosphoramidites)三类单齿磷配体以及由这三类配体衍生出的其他应用.

Since the 21st century,the study of chiral monophosphorous ligands,especially chiral mono-phosphites ligands and mono-phosphoramidites ligands has attracted widespread attention.This kind of ligands was extensively used in various asymmetric catalytic reactions,for most of them were easily synthesized and showed good stability,high activity and high enantioselectivity.The diverse common monodentate phosphonites,phosphites,and phosphoramidites ligands and their applications in asymmetric hydrogenations over the past two decades are reviewed.