摘要
报道了铁催化的烷基过氧酰或者叔丁基过氧酯对1,3-共轭烯烃的Heck型脱羧烷基化反应.这个方法提供了一个有效的对1,3-共轭烯烃进行Heck型烷基化的途径,不但收率高,而且有些情况下具有很高的区位选择性.此方法也可以用来对生物活性分子进行后期Heck型烷基化修饰.
An iron-catalyzed decarboxylative Heck-type alkylation of conjugate 1,3-dienes with alkyl diacyl peroxides and t-butyl peresters is reported.This method offers an efficient approach to alkylation of 1,3-dienes with good yields,and in some cases with high selectivities.Late-stage alkylation of bioactive compounds was also found to be effective.
作者
王凯凯
陈绍维
李亚军
李达谅
鲍红丽
Wang Kaikai;Chen Shaowei;Li Yajun;Li Daliang;Bao Hongli(Biomedical Research Center of South China&College of Chemistry and Materials Science,Fujian Normal University,Fuzhou 350007;Key Laboratory of Coal to Ethylene Glycol and Its Related Technology,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou 350002)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2021年第7期2707-2714,共8页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.21871258,21922112,22001251)
福建师范大学校创新团队(No.IRTL1703)资助项目.
