芪贞颗粒对腹型肥胖患者脂代谢及血清超敏C反应蛋白、同型半胱氨酸的影响

Exploration of the eff ect of Qizheng Granules on lipid metabolism,serum hypersensitive C-reactive protein and homocysteine in patients with abdominal obesity

目的探讨芪贞颗粒对腹型肥胖患者脂代谢、血清超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)的影响。方法采用随机、对照的方法,将60名患者分成治疗组和对照组,每组30人。在饮食、运动治疗及维持原有降糖方案的基础上,分别加用芪贞颗粒和对照药,疗程12周。观察治疗前后患者血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、hs-CRP、Hcy的变化,评价其对腹型肥胖患者心脑血管疾病高危因子的调节作用。结果经12周治疗后,治疗组较对照组更能改善气虚证候(P<0.001)。治疗组TG、TC、LDL-C、hs-CRP下降(P<0.001),HDL-C、Hcy无明显变化(P>0.05);对照组TG、TC、HDL-C、LDL-C、Hcy治疗前后无差异(P>0.05)。治疗组治疗后TG、TC、LDL-c、hs-CRP较对照组降低更明显(P<0.05),而2组间HDL-c、Hcy变化无统计学差异(P>0.05)。结论芪贞颗粒可以明显改善腹型肥胖患者临床症状,调节血脂,减轻慢性炎症状态,从而可能有助于延缓患者动脉硬化的进程。

Objective To investigate the effect and significance of Qizhen Granules on the lipid metabolism,high-sensitivity C-reactive protein(hs-CRP)and homocysteine(Hcy)in patients with abdominal obesity.Methods Using a randomized and controlled method,60 patients were divided into a treatment group and a control group,with 30 subjects in each group.On the basis of the diet,exercise therapy and maintaining the original hypoglycemic regimen,Qizhen Granules and control drugs were added respectively for a course of 12 weeks.The changes in serum triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),hs-CRP and Hcy before and after treatment were observed to evaluate their regulatory eff ect on the high-risk factors of cardiovascular and cerebrovascular diseases in patients with abdominal obesity.Results After 12 weeks of treatment,the treatment group was able to improve the qi defi ciency syndrome better than the control group(P<0.001).In the treatment group,TG,TC,LDL-C and hs-CRP were decreased(P<0.001),while HDL-C and Hcy had no signifi cant changes(P>0.05).There were no diff erences in TG,TC,HDL-C,LDL-C and Hcy in the control group before and after treatment(P>0.05).After treatment,TG,TC,LDL-C,and hs-CRP in the treatment group were signifi cantly lower than those in the control group(P<0.05),but there was no signifi cant diff erence in the changes of HDL-C and Hcy between the two groups(P>0.05).Conclusion Qizhen Granules,can signifi cantly improve the clinical symptoms of patients with abdominal obesity,regulate blood lipids and reduce chronic inflammation,which may help delay the process of arteriosclerosis in patients.