中草药致肾损伤及其相关成分毒性机制研究进展

Research Progress of Toxicity Mechanisms in Kidney Injury Associated with Chinese Herbs and Its Compositions

中草药涉及的天然化合物具有相对复杂的活性成分,对肾脏有不同程度的损伤。肾脏作为人体重要的代谢与排泄中心,是毒性药物的首要靶器官,所以中药的肾毒性作用机制研究具有重要意义。部分中药在治疗大多数疾病中会通过不同机制诱发肾脏损伤。该文综述了中药诱导的肾损伤中氧化应激、细胞凋亡、炎症反应、线粒体损伤、纤维化、Na^(+)-K^(+)-ATP酶以及转运蛋白等多种途径相关进展,为防治中药肾损伤的研究提供参考。

The natural compounds derived from Chinese herbs are relatively complex and have different degrees of side effects on kidney.As an important metabolism and excretion center of human body,kidney is the primary target organ of toxic drugs.It is of great significance to study the nephrotoxicity mechanism of traditional Chinese herbs.In the treatment of most diseases,some Chinese herbs can induce kidney injury through different mechanisms.In this paper,we review the mechanisms of kidney injury induced by Chinese herbs,such as the progress of oxidative stress,apoptosis,inflammatory response,mitochondrial injury,fibrosis,Na^(+)-K^(+)-ATPase and transporter,to provide reference for the research on prevention and treatment of kidney injury induced by Chinese herbs.