肠道微生物与眼部疾病相关性研究进展

Advances in the research on correlation between intestinal microorganism and ocular diseases

肠道微生物在机体代谢、保护肠黏膜屏障及维持正常免疫调节功能等方面发挥着重要作用。此外,肠道微生物还参与眼部慢性炎症反应及免疫性疾病的发生发展,如干眼症、糖尿病视网膜病变、年龄相关性黄斑变性及葡萄膜炎等。本文对肠道微生物在常见眼部疾病发生发展中的分子机制、调控作用及其治疗前景进行综述。

Intestinal microorganisms play an important role in promotion of metabolism,protection of intestinal mucosal barrier and maintenance of normal immunomodulatory function.In addition,intestinal microorganisms are also involved in the occurrence and development of ocular chronic inflammation and immune diseases,such as dry eye,diabetic retinopathy,age-related macular degeneration and uveitis.In this paper,the molecular mechanisms of intestinal microorganisms in the occurrence and development of common ocular diseases and their therapeutic prospects were reviewed.